Interactions between 6-chloro-5-cyclohexyl-l-indancarboxylic acid (TAI-284) and biopolymers.

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Biological activities of metabolites of 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284: anti-inflammatory agent).

The pharmacological activities of five metabolites of an anti-inflammatory compound, 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284) were investi gated and compared with TAI-284 and phenylbutazone. The metabolite IIb (cis 3'-hydroxy-cyclohexyl, β-form) was almost equivalent to TAI-284 regarding anti inflammatory activity as estimated by the carrageenin edema test, and was mor...

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ژورنال

عنوان ژورنال: Folia Pharmacologica Japonica

سال: 1977

ISSN: 0015-5691,1347-8397

DOI: 10.1254/fpj.73.895